Heparin-binding EGF-like growth factor

Abstract

Are you a dorm miner looking for big catches within your sleeping couch during the time when you are not into your books? For the independent students, this is one place, apart from your favorite subject books, which gives you enjoyment, satisfaction and a stable income. Yes, your course will fetch you regular and dignified income. This is no less, and the extra advantage is that while books will help you to earn in future after one or two years, this mining platform will bring you money from the net second.

A Relief For The Student Miners

Now, pay your bills, buy your favorite outfit and gift your parents whatever you wish without depending anyone. This mining software and software-cum-hardware are designed only for the studying lot.

Tackling the biggest trouble for the learning lot

The biggest issue for the student miners and Bitcoin Trader is the time limitation. A major schedule of your daytime will be spent in the classrooms and libraries and practice sessions consume your evenings. Night-time is the study time and then, when is the mining time?

This mobile-friendly and desktop-friendly software can be worked upon anywhere, round the clock in 24 hours and has all the features to save your precious time. And, if you want more convenience added to these, the software-cum-hardware mining system is the savior. This hand-held device works efficiently even on the slowest internet connection and gives you the extra benefit of direct puzzle solving without registration or initial hiccups.

Two versions are available: Downloadable and cloud-mining.

Save your data and restart your mining from the point you left.

 No lag, no loss

Worried about missing out in the race of the quickest and the smartest? When the time you have is less, but the competitors are more, there are chances that you are left back. This advanced software keeps on giving you alert on the newest puzzles and their complexity level. You can decide on a single glance itself amidst any kind of activity, whether this puzzle is in your hands or not. When you select it, you get the direct option of solving along with useful tips.

The application ensures that you get at least a sure win every day and thus get stable earnings from the mine. The application is registered under the federal law under suitable sections, making the student miners out of the legal scanner.

What about the students?

Special discounted packs without maintenance fee and deposit make the app the most affordable one for you, while you learn to achieve big in life.

The epidermal growth factor receptor (HER1) has been implicated in regenerative growth and proliferative diseases of the human bladder epithelium (urothelium), however a cognate HER1 ligand that can act as a growth factor for normal human urothelial cells (HUC) has not been identified. Here we show that heparin-binding EGF-like growth factor (HB-EGF), an activating HER1 ligand, is an autocrine regulator of HUC growth. This conclusion is based on demonstration of HB-EGF synthesis and secretion by primary culture HUC, identification of HER1 as an activatable HB-EGF receptor on HUC surfaces, stimulation of HUC clonal growth by HB-EGF, inhibition of HB-EGF-stimulated growth by heparin and of log-phase growth by CRM 197, a specific inhibitor of HB-EGF/HER1 interaction, and identification of human urothelium as a site of HB-EGF precursor (proHB-EGF) synthesis in vivo. ProHB-EGF expression was also detected in the vascular and detrusor smooth muscle of the human bladder. These data suggest a physiologic role for HB-EGF in the regulation of urothelial proliferation and regeneration subsequent to mucosal injury. Expression of proHB-EGF is also a feature of differentiated vascular and detrusor smooth muscle in the bladder. Because proHB-EGF is known to be the high affinity diphtheria toxin (DT) receptor in human cells, synthesis of the HB-EGF precursor by human urothelium also suggests the possibility of using the DT-binding sites of proHB-EGF as an in vivo target for the intraluminal treatment of urothelial diseases.

PMID: 9062361 PMCID: PMC507911 DOI: 10.1172/JCI119230
[Indexed for MEDLINE] Free PMC Article