Combined cytogenetic and Y chromosome microdeletion screening

The initial step in stock trading is thought to be the toughest one, but there are equally compelling challenges in the trading field to be overcome in order to achieve the success that a trading market beams of. Rags to riches stories have always propelled the popularity of stock markets, traders, and investment brokers. Every now and then our social media, internet browsers and newsfeed highlight success stories of those who have made it big in this extremely risky business. In one second, you can become a millionaire and in the next second, you will be bankrupt.

Traits of a successful stock traders

We cannot depend on hard work, determination, and constant perseverance here like we say about other fields. Nothing can fully guarantee you success in trading, but these three traits are marks of a potential winner among the risk-takers. Let us talk about them.

Having a clear vision of what you expect from trading

I have a friend who didn’t know any basic knowledge about the terms and procedures in trading, but she was very sure about what she was looking to achieve by trading through Q Profit System. She wanted to invest in small assets with quick turnovers and minimum risk and thereby getting consistent, rapid profits within a short time. Her individual profits were very small, but their cumulative sum after a specific period was enough to provide an appreciable startup sum, as she hardly lost in the trades. The trading objective and the knowledge about the trading asset you are investing, both impart credibility to your trade business.

Being continuous and updated

In any field, if you do not remain in the track and keep yourself updated about any significant modifications, like new prospective market entries, market trends, global cues, financial policies etc, you are likely to find it difficult to get a second successful run. A good player will always be in the chase, even if remaining dull at times.

Not slow and steady, but diligent and proactive win the race

Take your time in learning about the trading market, but do not make it too slow that by the time you acquire knowledge about the current year’s trends, the next financial year starts to knock at the market. And do not be too fast and greedy to have a reckless run in the market, eventually falling into losses. Presence of mind, timely use of logical reasoning and overcoming emotional disturbances will help you in taking the right real-time decisions in the stock market.

We evaluated the frequency of chromosomal aberrations and microdeletions of the Y chromosome in a sample of 204 patients included in an intracytoplasmic sperm injection (ICSI) programme. The prevalence of Y chromosome deletions in males with severely or only moderately reduced sparm counts is mainly unknown, so that patients were chosen with sperm counts ranging from mild oligozoospermia to azoospermia. While six out of 158 (3.8%) patients showed constitutional chromosomal aberrations, only two out of 204 (0.98%) patients were diagnosed with a microdeletion of Yq11. One had a terminal deletion in subinterval 6 of Yq11.23 which included the DAZ gene and a corresponding sperm count < 0.1 x 10(6) spermatozoa/ml. The second patient had an isolated deletion of marker Y6PH54c, a more proximal site in subinterval 5 on Yq11.23, but repeatedly showed sperm counts of 3-8 x 10(8) spermatozoa/ml. Thus, of the 158 patients who underwent a combined cytogenetic and Y-microdeletion screening, eight patients (5.1%) showed chromosomal abnormalities, either at the cytogenatic (n = 6) or the molecular level (n = 2). In conclusion, although rare in number, microdeletions of the Y chromosome can also be observed in patients with moderately reduced sperm counts. A more proximal site of the deletion breakpoint does not necessarily imply a more severe impairment of spermatogenesis than a distal deletion site. In our sample, the overall frequency of constitutional chromosomal aberrations exceeded the incidence of microdeletions of the Y chromosome even in patients with idiopathic azoo- or severe oligozoospermia.

PMID: 9294854
[Indexed for MEDLINE]